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KMID : 0545120210310111465
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Journal of Microbiology and Biotechnology
2021 Volume.31 No. 11 p.1465 ~ p.1480
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Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
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Ahmed Aqsa
Ahmad Abdullah
Li Renhan
AL-Ansi Waleed
Fatima Momal
Mushtaq Bilal Sajid
Basharat Samra
Li Ye
Bai Zhonghu
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Abstract
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Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum, (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii, Corynebacterium glutamicum, and Yarrowia lipolytica, (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications.
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KEYWORD
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Violacein, heterologous production, industrial applications, biological applications, synthetic biology, metabolic engineering
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